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KMID : 1146920180480030301
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Journal of Pharmaceutical Investigation
2018 Volume.48 No. 3 p.301 ~ p.312
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Microemulsion for nasal delivery of Asenapine maleate in treatment of schizophrenia: formulation considerations
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Patel Mrunali R.
Hirani Suresh N.
Patel Rashmin B.
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Abstract
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The objective of this study was to develop and evaluate the microemulsion (ME) and mucoadhesive microemulsion (MME) for intranasal delivery of Asenapine maleate (APM) for the treatment of schizophrenia. APM loaded ME (AME1 to AME5) and MME (AMME) were prepared by spontaneous microemulsification method and evaluated for drug content, globule size and polydispersity index, % transmittance, zeta potential, pH, viscosity, conductivity, drug content, refractive index, ex vivo diffusion study using sheep nasal mucosa, nasal ciliotoxicity study and Fourier transform infrared spectroscopy study. The AME4 (5 mg/mL of APM) containing 11% Capmul MCM, 38% Smix (Tween80: Propylene glycol (1:1)) and 51% (v/v) water that displayed optical transparency of 99.77%, globule size of 79.50 nm, polydispersity index (PDI) of 0.356 were selected for preparation of MME. The highest diffusion coefficient (P?
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KEYWORD
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Asenapine maleate, Microemulsion, Nasal delivery, Schizophrenia
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